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In high doses, the side effects of flavonoid supplementation may outweigh the good. Different flavonoids may have different effects; for instance, quercetin can cause kidney damage in large doses. Other side effects can include nausea and headaches. Most experts recommend getting flavonoids through dietary sources, rather than as supplements. As with any alteration to a health regimen, it is best to speak with your doctor before making major changes to your nutrient intake. *