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Interactions
None well documented. Theoretically, patients self-medicating with E. ulmoides may experience additive adverse effects if taking anticoagulant, antiplatelet, low–molecular weight heparins, or thrombolytic medications. Additive adverse effects with medications for diabetes, high blood pressure, and weight reduction may also be possible.
Adverse Reactions
One clinical study documented moderately severe headache, dizziness, edema, and onset of a cold. Serum glucose levels increased by 3 ± 2 mg/dL from a baseline of 95 ± 3 mg/dL. Serum creatinine increased by 0.02 ± 0.01 mg/dL from a baseline of 0.87 ± 0.03 mg/dL.
Toxicology
No information in humans is available. One study found no acute toxic symptoms for mice treated with 6.68 g/kg of Eucommia lignans after 14 days. The 6.68 g/kg dose is equivalent to almost 334 times the human clinical dose. No acute toxicity in rats was exhibited for 1,200 mg/kg. No toxicity was evident as determined by clinical appearance, histopathology, and serum chemistry for repeated dosing of 200, 600, and 1,200 mg/kg over 28 days. *
