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When taken by mouth: Eicosapentaenoic acid (EPA) is LIKELY SAFE for most adults. It has been used safely in studies for up to 7 years. Most side effects are mild and may include nausea, diarrhea, discomfort in the upper abdomen, or belching. Taking EPA with meals can often decrease these side effects. But people should limit intake of EPA and other omega-3 fatty acids to 3 grams per day, with no more than 2 grams per day from a dietary supplement unless approved by a healthcare provider. Doses of EPA and other omega-3 fatty acids greater than 3 grams per day is POSSIBLY UNSAFE. Taking more than 3 grams per day of omega-3 fatty acids might slow blood clotting and may increase the chance of bleeding.
When given by IV: Eicosapentaenoic acid is POSSIBLY SAFE for most people when given by IV with the approval of a healthcare provider. It is usually well tolerated.
Special Precautions & Warnings:
Pregnancy and breast-feeding: There isn't enough reliable information to know if eicosapentaenoic acid is safe to use when pregnant or breast-feeding. Stay on the safe side and avoid using more than food amounts.
Irregular heartbeat (arrhythmia): In people with a history of arrhythmias, eicosapentaenoic acid may further increase risk of irregular heartbeat. If you have had arrhythmias, talk with your healthcare provider before you start taking eicosapentaenoic acid.
Aspirin-sensitivity: If you are sensitive to aspirin, eicosapentaenoic acid might affect your breathing.
High blood pressure: Eicosapentaenoic acid might lower blood pressure. In people who are already taking medications to lower their blood pressure, adding eicosapentaenoic acid might make blood pressure drop too low. If you have high blood pressure, discuss using eicosapentaenoic acid with your healthcare provider, before you start taking it.
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