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To date, very little is known about the safety of using diindolylmethane supplements regularly or in the long term.
Due to diindolylmethane's potential to affect estrogen metabolism, there's some concern that taking diindolylmethane supplements could aggravate hormone-sensitive conditions (including hormone-dependent cancers, endometriosis, and uterine fibroids).
According to one report, an otherwise healthy woman reported central serous chorioretinopathy—a condition resulting in visual impairment—after excessive daily intake of diindolylmethane for two months. After discontinuing the supplements, her symptoms resolved after eight weeks.
A skin rash with eosinophilia (raised levels of eosinophils often occurring in response to some form of allergic reaction or drug reaction) was reported following the use of diindolylmethane. Muscle and joint pain, particularly in the hips and knees, have been reported.
Given the safety concerns, it's important to seek medical advice prior to using diindolylmethane supplements. Women who are pregnant or nursing shouldn't take diindolylmethane supplements. Also, people who are being treated for cancer should not take it without a doctor's prescription.
You can get additional tips on using supplements but it's important to note that self-treating a chronic condition with diindolylmethane and avoiding or delaying standard care can have serious consequences. *
