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As of now, there’s limited clinical evidence about the safety of butyric acid.
In one study that found that butyric acid supplementation may improve IBS symptoms, the researchers reported no side effects at a dose of 300 mg per day.
However, if you’re pregnant or breastfeeding, you may want to avoid butyric acid supplementation.
One animal study found that giving pregnant and breastfeeding rats sodium butyrate led to insulin resistance and increased fat storage in their offspring. *
Butyrate is considered safe and beneficial in the quantities normally produced by a healthy gut flora. Eating dietary fiber instead of supplements to increase butyrate likely prevents any risk of overdose.
In a rat study, supplementation of butyrate during pregnancy and breastfeeding led to insulin resistance and fat accumulation in the offspring. If you are pregnant or nursing, it is best to avoid butyrate supplements until we know more. *
