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Keep in mind that the safety profile of apigenin is relatively unknown, given the lack of well-designed clinical studies. The list of side effects below is not a definite one and you should consult your doctor about other potential side effects based on your health condition and possible drug or supplement interactions.
In clinical trials, adverse effects were rare and mild. They included digestive discomfort (oral chamomile extract) and skin reactions (topical chamomile gel). Because the trials didn’t use pure apigenin, these effects could have been caused by any other chamomile compounds.
Importantly, apigenin has estrogenic activity. Women with a history of estrogen-responsive cancers or on hormone replacement therapy should be especially cautious with apigenin and consult with their doctors before supplementing with this flavonoid.
While no toxicity studies have been conducted in humans, high apigenin doses (100mg/kg) caused liver damage in rats. *
