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Alpha-GPC was safe in all clinical trials. In a fraction of patients, it caused mild side effects such as:
- Heartburn
- Nausea
- Irritability
- Headache
In safety studies on dogs and rats, megadoses (up to 3,000 mg/kg) only slightly reduced the animals’ activity. Researchers concluded that long-term (26 weeks) alpha-GCP consumption of 150 mg/kg (over 10 g daily for adult men) bears no health risks.
Due to the lack of safety data, children and pregnant women may want to avoid alpha-GPC. *
