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The following doses have been studied in scientific research:
ADULTS
BY MOUTH:
- For a condition in which the body make abnormal red blood cells that build up iron (sideroblastic anemia): Initially, 200-600 mg of vitamin B6 is used. The dose is decreased to 30-50 mg per day after an adequate response.
- For vitamin B6 deficiency: In most adults, the typical dose is 2.5-25 mg daily for three weeks then 1.5-2.5 mg per day thereafter. In women taking birth control pills, the dose is 25-30 mg per day.
- For high levels of homocysteine in the blood (hyperhomocysteinemia): For reducing high levels of homocysteine in the blood after meals, 50-200 mg of vitamin B6 has been taken alone. Also, 100 mg of vitamin B6 has been taken in combination with 0.5 mg of folic acid.
- For an eye disease that leads to vision loss in older adults (age-related macular degeneration): 50 mg of vitamin B6 in the form of pyridoxine has been used daily in combination with 1000 mcg of vitamin B12 (cyanocobalamin) and 2500 mcg of folic acid for about 7 years.
- For hardening of the arteries (atherosclerosis): A specific supplement (Kyolic, Total Heart Health, Formula 108, Wakunga) containing 250 mg of aged garlic extract, 100 mcg of vitamin B12, 300 mcg of folic acid, 12.5 mg of vitamin B6, and 100 mg of L-arginine daily for 12 months has been used.
- For kidney stones: 25-500 mg of vitamin B6 has been used daily.
- For morning sickness: 10-25 mg of vitamin B6 taken three or four times per day has been used. In people who don't respond to vitamin B6 alone, a combination product containing vitamin B6 and the drug doxylamine (Diclectin, Duchesnay Inc.) is used three or four times per day. Also, another product containing 75 mg of vitamin B6, 12 mcg of vitamin B12, 1 mg of folic acid, and 200 mg of calcium (PremesisRx, KV Pharmaceuticals) is used daily.
- For symptoms of premenstrual syndrome (PMS): 50-100 mg of vitamin B6 is used daily, alone or along with 200 mg of magnesium.
- For treating a movement disorder often caused by antipsychotic drugs (tardive dyskinesia): 100 mg of vitamin B6 per day has been increased weekly up to 400 mg per day, given in two divided doses.
INJECTED INTO THE MUSCLE:
- A condition in which the body makes abnormal red blood cells that build up iron (sideroblastic anemia): 250 mg of vitamin B6 daily, reduced to 250 mg of vitamin B6 weekly once adequate response is achieved.
CHILDREN
BY MOUTH:
- For kidney stones: Up to 20 mg/kg daily in children aged 5 years and up.
INJECTED INTO THE VEIN OR MUSCLE:
- For seizures: 10-100 mg is recommended for seizures in newborns who are dependent on vitamin B6. *
