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The following doses have been studied in scientific research:
ADULTS
BY MOUTH:
- For mild to moderate low mood or depression:
- In most studies, St. John's wort extract was standardized to 0.3% hypericin content and used at doses of 300 mg 3 times daily.
- Some studies have used St. John's wort extract standardized to 0.2% hypericin at doses of 250 mg twice daily.
- St. John's wort extract standardized to 5% hyperforin has been used at doses of 300 mg 3 times daily.
- For symptoms of menopause:
- St. John's wort extract (Hypiran, Poursina Pharmaceutical Mfg. Co., Tehran, Iran) containing 0.2 mg/mL hypericin, taken in doses of 20 drops 3 times daily for 2 months has been used.
- St. John's wort 300mg 3 times daily for 3-4 months has been used.
- For emotional distressed caused by extreme focus on a physical symptom (somatic symptom disorder): a specific extract (LI 160, Lichtwer Pharma) 600 mg/day has been used.
APPLIED TO THE SKIN:
- For wound healing: An ointment containing a 5% St. John's wort extract applied three times daily beginning 24 hours after a C-section and continued for 16 days has been used.
CHILDREN
BY MOUTH:
- For mild to moderate depression: 150-300 mg of St. John's wort three times daily for 8 weeks in children 6-17 years-old has been used. A specific St. John's wort extract (LI 160, Lichtwer, Pharma) 300-1800 mg in three divided doses daily for up to 6 weeks has been used.
Do not suddenly stop taking St. John's wort. This might cause unpleasant side effects. If you decide to stop taking St. John's wort, reduce the dose slowly over time.
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