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There are limited human studies on sesamin, but it appears that oral ingestion of around 100-150mg of sesamin is sufficient to raise bodily sesamin stores to the level where it can preserve Vitamin E in the body; this indirect antioxidative effect may be the most practical reason to supplement sesamin.
If using sesame seeds to get your sesamin from, human studies have used 50-75g of sesame seeds with some success and rat studies tend to use 100-fold the oral dose of sesame seeds relative to sesamin (which would make the aforemented dose of 100-150mg as minimum being 10-15g of sesame seeds). *