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There is no safe and effective dose of Rehmannia because no sufficiently powered study has been conducted to find one. That being said, clinical trials have produced beneficial results at certain doses.
Among available studies, dosages range from as little as 3 mg of Rehmannia to as much as 400 mg. However, many of these studies also included other herbs, so the dosage of Rehmannia was lower than it might have been if this herb was used alone.
One of the problems with the studies on Rehmannia in humans is a lack of dosage information. Some studies used Liuwei Dihuang Pills but didn’t report the amount of each component in the pills. This makes it difficult to determine what an optimal dose should be. *