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Supplementation of pterostilbene for the purpose of aiding glucose and lipid metabolism tends to be around 20- 40 mg/kg oral ingestion in rats, which is an estimated human dosage range of:
- • 215-430 mg for a 150 lb person
- • 290-580 mg for a 200 lb person
- • 365-730 mg for a 250 lb person
Possible anxiolytic properties of pterostilbene are seen at 1-2mg/kg in mice, which is an estimated human dose of:
- • 5.5-11 mg for a 150 lb person
- • 7.3-14.5 mg for a 200 lb person
- • 9-18 mg for a 250 lb person
Which is notable as 5-10 mg/kg in these mice (slightly over double the dose) has failed to have the same anxiolytic effects, suggesting a bell-curve that may favor lower dosages such as is found in food consumption rather than higher dosages from supplementation.
Limited human studies have used either 50mg twice a day or 125 mg twice a day, and the addition of Grape seed extract (100 mg at both dosing times) with the low dose may mitigate some adverse effects on cholesterol seen with pterostilbene in isolation. *
