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The following doses have been studied in scientific research:
BY MOUTH:
- For hormone replacement therapy (HRT): 200 mg micronized progesterone (Prometrium) per day is typically taken for 12 days of a 25-day cycle with 0.625 mg conjugated estrogens.
- For inability to become pregnant within a year of trying to conceive (infertility): 300 mg micronized progesterone per day is usually taken for about 30 days after the embryo has been placed in the uterus.
- For preventing preterm birth: 100 mg micronized progesterone twice daily starting at week 20 of pregnancy has been used.
APPLIED TO THE SKIN:
- For symptoms of menopause: 20 mg progesterone cream (equivalent to 1/4 teaspoon Progest cream) is typically applied daily to rotating places on the body including upper arms, thighs, or breasts.
INSIDE THE VAGINA:
- For breast pain (mastalgia): a typical dose of 4 grams of vaginal cream containing 2.5% natural progesterone is placed inside the vagina from the 19th to the 25th day of a 28-day cycle.
- For absence of menstrual periods (amenorrhea): one applicator (90 mg) of progesterone gel (Crinone 4% or 8%) is typically placed inside the vagina every other day for 6 days per month.
- For reducing abnormal thickening of the lining of the uterus (endometrial hyperplasia): a dose of 90 mg (Crinone 8%) or 100 mg progesterone cream placed inside the vagina daily from day 10 to day 25 or on days 17, 19, 21, 23, 25, and 27 of a 28-day cycle has been used.
- For inability to become pregnant within a year of trying to conceive (infertility): 90 mg progesterone (Crinone 8%) or 100-600 mg of other types of progesterone have been placed inside the vagina every day for about 2 weeks after the embryo has been placed in the uterus.
- For preventing premature labor: 90-400 mg progesterone in the form of gel or an insert has been placed in the vagina every day starting at about 18-22 weeks of pregnancy.
AS AN INJECTION:
- For inability to become pregnant within a year of trying to conceive (infertility): 50-100 mg progesterone each day with in vitro fertilization has been used. *
