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The following doses have been studied in scientific research:
ADULTS
BY MOUTH:
- For acne: Tablets containing 750 mg of niacinamide, 25 mg of zinc, 1.5 mg of copper, and 500 mcg of folic acid (Nicomide) once or twice daily have been used. Also, 1-4 tablets containing niacinamide, azelaic acid, zinc, vitamin B6, copper, and folic acid (NicAzel, Elorac Inc., Vernon Hills, IL) have been taken daily.
- For vitamin B3 deficiency symptoms such as pellagra: 300-500 mg per day of niacinamide is given in divided doses.
- For diabetes: Niacinamide 1.2 grams/m2 (body surface area) or 25-50 mg/kg is used daily for slowing progression of type 1 diabetes. Also, 0.5 grams of niacinamide three times daily is used to slow the progression of type 2 diabetes.
- For high levels of phosphate in the blood (hyperphosphatemia): Niacinamide from 500 mg up to 1.75 grams daily in divided doses is used for 8-12 weeks.
- For cancer of the larynx: 60 mg/kg of niacinamide is given 1-1.5 hours before inhaling carbogen (2% carbon dioxide and 98% oxygen) before and during radiotherapy.
- For skin cancers other than melanoma: 500 mg of niacinamide once or twice daily for 4-12 months.
- For treating osteoarthritis: 3 grams of niacinamide per day in divided doses for 12 weeks.
ON THE SKIN:
- Acne: A gel containing 4% niacinamide twice daily.
CHILDREN
- Acne: In children at least 12 years of age, 1-4 tablets containing niacinamide, azelaic acid, zinc, vitamin B6, copper, and folic acid (NicAzel, Elorac Inc., Vernon Hills, IL) are taken daily.
- For pellagra: 100-300 mg of niacinamide is given daily in divided doses.
- For type 1 diabetes: 1.2 grams/m2 (body surface area) or 25-50 mg/kg of niacinamide is used daily for slowing progression of or preventing type 1 diabetes. *
According to the U.S National Library of Medicine's MedlinePlus, the following dosages are recommended:
- For osteoarthritis, 3 grams of niacinamide are to be taken daily for 12 weeks. The daily dose is to be divided into small doses throughout the day.
- For hyperphosphatemia, between 500 mg to 1.5 grams of niacinamide is to be taken daily for eight to 12 weeks. As with osteoarthritis, this daily dose should be divided into small doses throughout the day.
- For pellagra, 3g of niacinamide is to be taken daily and divided into small doses.
- For acne, supplements that contain 750 mg of niacinamide combined with 25 mg of zinc, 1.5 mg of copper, and 500 mcg of folic acid is to be taken once or two times daily. *
