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The dosage of magnolia officinalis to take varies on goal. For those related to GABA (including anxiety, sedation, stress, and epilepsy) an oral dose of 0.2mg/kg in mice appears effective and suggests very lose doses (5-10 mg) are effective in humans.
For those goals related to learning or depression, higher doses may be required. This usually means 15-30mg/kg in rats, and suggests a human dose of:
- • 160-330 mg for a 150lb person
- • 220-440 mg for a 200lb person
- • 270-550 mg for a 250lb person
The above doses refer to the total neolignans (usually magnolol plus honokiol), which are usually at 1-10% of a basic bark extract unless otherwise concentrated. *
MBE is commercially available in the United States and throughout Europe, as documented by Internet search engines. Dosage varies depending on the condition treated, with weight loss products containing MBE available mostly in powder form. Several strengths are available for Relora, a patented blend marketed as "a natural stress management supplement" that includes MBE. Dosing recommendations include taking a 300 mg capsule of Relora 2 to 3 times per day. A small, randomized, controlled study treated patients with one 60 mg tablet of MBE daily to help relieve menopausal symptoms. *
