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The following doses have been studied in scientific research:
BY MOUTH:
- For headache or improving mental alertness: The typical dose of caffeine is up to 250 mg per day, which is about 2 cups of coffee. Even a single cup of coffee with caffeine can be used.
- For Parkinson disease: Three to four cups of caffeinated coffee per day or 421 mg to 2716 mg total caffeine. However, a significantly lower risk of developing Parkinson disease has also been associated with as little as 124 mg to 208 mg of caffeine (approximately one to two cups of coffee). In women, more moderate caffeinated coffee intake, one to three cups per day, seems to be best.
- For death from any cause: At least one cup of ground, instant, or decaffeinated coffee per day has been used long-term.
- For gallbladder disease: 400 mg or more of caffeine per day, which is about two or more cups of coffee. However, drinking at least 800 mg caffeine per day (four or more cups of coffee) seems to work best.
- For high cholesterol: Six to eight cups of caffeinated coffee per day has been used.
- For diabetes: 900 mg caffeine per day (six or more cups of coffee per day) long-term.
- Impaired movement of food through the intestines after surgery: 100 mL of coffee three times a day starting after surgery and continuing until the first bowel movement has been used.
The choice of coffee, grind, amount of coffee to water, and other factors determine flavor and strength of coffee.
Brewed coffee contains around 100-150 mg caffeine per cup. Instant coffee contains 85-100 mg caffeine per cup. Decaffeinated coffee contains approximately 8 mg caffeine per cup. Darker roasts contain less caffeine due to the roasting process.
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