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For reducing homocysteine levels, a daily dose of 3–6 g is most commonly used in research. In healthy people, a daily dose of 1.5–3 g might be just as effective as higher doses.
A dosage of 2.5 g, typically split into two 1.25 g doses, has been used to improve resistance exercise performance.
Studies on liver fat and fibrosis have used a dosage of 20 g per day, divided into two 10 g doses.
High doses of betaine seem to be well tolerated by most people, but like any osmolyte, it can cause diarrhea at high doses. High doses of betaine can also increase total cholesterol and LDL-cholesterol levels. *
